Cordyceps Health Benefits Research

Cordyceps sinensis extract is Solid fermentation culture , the substrate material is millet. 

Cordyceps sinensis (CS-4 strain,mycelium)(also called :Paecilomyces hepiali Chen et Dai ):During the research and development of cordyceps mycelium, researchers selected the most effective and most similar to wild cordyceps – strain “4”, which was called Cs-4, among the strains numbered from 1 to more than 200. Cs-4 is the only approved fermented cordyceps mycelium in China in the world, which is recognized as the closest to wild cordyceps sinensis strains.

Here are some important research papers related to the benefits of CS-4:

  1. Li, S. P., Zhang, G. H., & Wang, Y. T. (2006). Cordyceps as an Herbal Drug. In Herbal Medicine: Biomolecular and Clinical Aspects (2nd edition). Chapter 9.https://www.ncbi.nlm.nih.gov/books/NBK92758/
  2. Liu, Y., Wang, J., Wang, W., Zhang, H., Zhang, X., Han, C., … & Zhu, D. (2001). The Hepatoprotective Effects of Cordyceps sinensis Extract on Antituberculous Drugs-Induced Liver Injury in Rats. Pharmacological Research, 43(2), 77-82.
  3. Li, J. Y., Cao, H. Y., Liu, P., Cheng, G. H., Sun, M. Y., Qi, L. W., & Li, P. (2012). Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR. Life Sciences, 91(23-24), 1133-1138.
  4. Xiao, J., Hu, D. D., Zhang, D., Hu, Y., Wang, L., & Yang, Y. (2014). Cordycepin Attenuates Traumatic Brain Injury-Induced Neuroinflammatory Responses via Impeding PUMA-Dependent Mitochondrial Apoptosis Pathway. Neurochemical Research, 39(6), 1251-1258.
  5. Sun, Y., Shao, Y., Zhang, Z., Wang, L., Mariga, A. M., Pang, G., … & Xu, X. (2014). Cordycepin Suppresses TNF-α-Induced NF-κB Activation by Reducing p65 Transcriptional Activity, Inhibiting IκBα Phosphorylation, and Blocking IKKγ Ubiquitination. International Immunopharmacology, 18(3), 593-600.
  6. Lu, M. C., El-Shazly, M., Wu, T. Y., Du, Y. C., Chang, T. T., Chen, C. F., … & Chang, F. R. (2013). Recent Research and Development of Cordyceps Militaris. Fitoterapia, 84, 17-24.
  7. Chen, Y., Yang, X., Yang, B., & Zhu, M. (2013). Cordyceps Sinensis (CS) and Cordyceps Militaris (CM) Extracts Modulate Interferon Gamma (IFN-γ) and Interleukin 10 (IL-10) Production in Normal Mouse Splenocytes In Vitro. Pharmaceutical Biology, 51(6), 750-755.
  8. Huang, B. M., Lin, Y. C., Hsu, Y. Y., Suen, L. T., & Chien, S. C. (2016). Ethanol Extract of Cordyceps cicadae Exerts an Anti-Neuroinflammatory Effect by Inhibiting Proinflammatory Mediators. Journal of Medicinal Food, 19(1), 75-84.
  9. Kim, H. G., Shrestha, B., Lim, S. Y., Yoon, D. H., Chang, W. C., Shin, D. J., … & Kim, S. Y. (2014). Cordycepin Inhibits LPS-Induced Inflammatory Responses by Modulating Nrf2-Mediated Signaling in BV2 Microglial Cells. International Immunopharmacology, 19(2), 941-947.
  10. Wang, J. W., Yue, G. G., Keng, C. L., Leung, P. C., Tong, Y., Lau, C. B., & Wong, C. K. (2014). Hypoglycemic Effects of Extract from Solid-State Fermented Cordyceps sinensis Culture. Asia Pacific Journal of Clinical Nutrition, 23(1), 1-8.